Advanced stem cell treatment for limb girdle muscular dystrophy in India
What if you could find renewed hope in treating the symptoms of Limb-Girdle Muscular Dystrophy (LGMD)?
Don’t give up hope!
Thanks to advancements in stem-cell therapy, gene therapy, and endless studies related to LGMD, the currently available treatments show more encouraging outcomes than in the past.
Stem cell therapy is believed to involve the use of cells that play a major role in the regeneration of skeletal muscle.
The treatment using bone marrow-derived cells for muscular dystrophy helps in the remodeling of tissues, lowering inflammation, and preventing cell death.
With the right approach and knowledge, you can get back to experiencing life to its fullest again.
Let us explore a short story about our patient, Peter Robert, and his son.
Peter Robert is a 40-year-old businessman who lives in Lagos, Nigeria with his wife and their 12-year-old son, Jack. Peter is a hardworking and caring father who enjoys spending time with his son, especially playing sports and going on outdoor adventures.
Jack is a talented athlete, always eager to join his dad in any kind of activity.
One day, Peter noticed that Jack was having difficulty climbing stairs and getting up from a seated position. He also noticed that Jack’s movements were slower and more deliberate than usual.
Concerned about his son’s health, Peter took Jack to see their family physician. After a series of tests and consultations with specialists, Jack was diagnosed with Limb Girdle Muscular Dystrophy (LGMD), a progressive genetic disorder that affects the muscles of the hips and shoulders.
Peter was devastated to learn about Jack’s diagnosis, but he knew he had to stay strong for his son. He immediately began researching treatments and therapies that could help his son manage the symptoms of LGMD. That’s when he came across MedicoExperts, that specializes in quality healthcare services.
Peter reached out to MedicoExperts and was connected with a team of expert physicians who were well-versed in LGMD.
The team guided Peter through the treatment options available to Jack. With the help of stem-cell therapy wherein stem cells were used to repair and regenerate weakened muscle tissues, Jack was able to regain some of his mobility.
Additionally, with the support of physical and occupational therapy, and assistive devices like braces he was also able to improve his motor skills and overall quality of life.
The team’s goal was to enhance his vital capacity. To achieve this, he was provided with passive exercises, exercises to improve bilateral hand functions, and breathing exercises.
The MedicoExperts team also provided emotional support to Peter and his family, helping them cope with the challenges of living with LGMD. They held regular consultations with Jack’s physicians, ensuring that he received the best possible care and treatment.
Over time, Jack’s condition improved, and he was able to regain some of his mobility with the help of therapy and assistive devices. Peter was grateful for the immense guidance provided by MedicoExperts, which made all the difference in his son’s recovery.
Today, Jack is a happy and active teenager who continues to pursue his love for sports and outdoor activities. Peter is proud of his son’s resilience and strength, and he is grateful to MedicoExperts.
With the ongoing support of the team, Peter was able to stay informed about the latest developments in LGMD research and treatment. He learned about promising new therapies, clinical trials, and support groups for families affected by LGMD.
This was a short yet inspiring story of Peter and his son.
If you are living with Limb Girdle Muscular Dystrophy, we understand your struggle and we want to help. Without further ado, let us see how you can manage your Limb Girdle Muscular Dystrophy symptoms and increase your quality of life.
What is Limb-girdle muscular dystrophy?
Limb-girdle muscular dystrophy (LGMD) is a group of inherited conditions that weaken the muscles in the hips, upper arms, pelvic area, thighs, and shoulders. It is caused by mutations in the genes and can vary greatly in severity.
The shoulder and hip areas are supported by a unique skeletal structure called the limb girdles.
These are comprised of the shoulder girdle and pelvic girdle, respectively.
A group of conditions is associated with these limb girdles, which are characterized by muscle weakness and wasting. This connection is what has given this set of disorders the name “Limb-girdle muscular dystrophy”.
What are the signs and symptoms of Limb-girdle muscular dystrophy?
The signs and symptoms of Limb-girdle muscular dystrophy vary from person to person and can range from mild to severe.
Here are some common signs and symptoms include:
- muscle weakness,
- decreased coordination,
- difficulty walking and climbing stairs,
- getting up from a seated position,
- lifting objects overhead
- pain in the hips and shoulders,
- fatigue,
- trouble breathing,
- difficulty swallowing, and/or
- muscle cramps, and joint stiffness.
How LGMD affects the muscles?
Limb-girdle muscular dystrophy affects the muscles in three ways.
– First, LGMD causes weakness and wasting of muscles, which can lead to difficulty in walking and performing everyday activities.
– Second, LGMD causes muscle contractions, spasms, and cramps, which can be painful.
– Lastly, LGMD causes joint stiffness in the hips and shoulders, making it difficult to move the affected areas.
What are the types of LGMD and their causes?
Limb-girdle muscular dystrophy is complex because it can result from various mutations in genes. These genes produce proteins that are essential for muscle maintenance and repair.
From building blocks to cell signaling, every protein plays its part in maintaining the physical integrity of muscle tissue and enabling its contraction. Some proteins even help with cellular waste disposal or membrane repair.
It is truly an intricate and holistic process that involves many different functions working together.
Within this disorder, there are distinct classifications based on both its inheritance pattern and its genetic cause.
For instance, limb-girdle muscular dystrophy type 1 is quite different from type 2.
- Type 1 is inherited via an autosomal dominant pattern, whereas
- Type 2 follows an autosomal recessive pattern.
- Limb-girdle muscular dystrophy Type 2A is also referred to as Calpainopathy. Around 30% of cases are accounted for by this being the most prevalent. The CAPN3 gene is usually affected.
- Dysferlinopathy is the name given to Type 2B Limb-girdle muscular dystrophy. This is caused by mutations in the DYSF gene.
- Other forms of this debilitating condition are Sarcoglycanopathies, represented by limb-girdle muscular dystrophy Types 2D, 2E, 2C, and 2F, caused by mutations in the SGCA, SGCB, SGCG, and SGCD genes respectively. Each subtype presents unique challenges to patients and healthcare providers.
Understanding these can help guide research efforts and pave the way for more effective treatments in the future.
How is Limb-girdle muscular dystrophy diagnosed?
The diagnosis of Limb-girdle muscular dystrophy (LGMD) is typically made through a combination of clinical evaluation, genetic testing, and specialized tests.
First, a physician will perform a thorough physical examination and take a detailed medical history, including information about the patient’s family history.
They will look for signs of muscle weakness and wasting, as well as difficulty with mobility and daily activities.
Genetic testing is an important component of the diagnostic process for LGMD. There are several different genes associated with LGMD, and genetic testing can identify mutations in these genes that are responsible for the disease.
The testing may involve a blood sample, saliva sample, or muscle biopsy, depending on the type of LGMD suspected.
In addition to genetic testing, specialized tests may also be used to evaluate muscle function and assess the extent of muscle damage.
These may include electromyography (EMG) to measure the electrical activity of muscles, nerve conduction studies to evaluate nerve function, and imaging tests such as MRI or CT scans.
Finally, a muscle biopsy may be performed to examine the structure and composition of muscle tissue. This can help to confirm the diagnosis of LGMD and distinguish it from other muscle disorders.
Overall, the diagnosis of LGMD is complex and requires a multidisciplinary approach involving specialized testing and expertise from a team of healthcare professionals.
Conventional treatment options - current approaches to managing LGMD
A key component of managing LGMD is physical therapy, which can help improve muscle strength, flexibility, and range of motion.The patient will collaborate with a physical therapist to create a customized exercise plan that suits their individual requirements and capabilities.
Occupational therapy can help patients with LGMD adapt to changes in their mobility and independence. This may involve training in the use of assistive devices such as braces or wheelchairs, as well as techniques for performing daily activities with limited mobility.
There are currently no medications that can cure or reverse LGMD, but certain drugs may help manage symptoms and slow the progression of the disease. For example, corticosteroids may be used to improve muscle strength and function, while drugs that target inflammation may help reduce muscle damage.
As the disease progresses, patients with LGMD may experience respiratory complications. Respiratory therapy can help manage these complications, which may include the use of breathing devices or machines to help with breathing.
In some cases, surgery may be recommended to help manage the symptoms of LGMD. For example, surgery may be used to correct scoliosis or other spinal deformities or to release contractures that can occur in the muscles and tendons.
Advanced treatment option: Stem cell therapy for limb girdle muscular dystrophy
In addition to these conventional treatment options, there are also several emerging therapies and clinical trials being developed to treat LGMD.
These include gene therapy, stem cell therapy, and novel drug therapies that target specific genetic mutations associated with the disease.
Stem cell therapy has the potential to transmit progressive muscle proteins and restore the stem cell pool. Thereafter making it a promising treatment option for muscular dystrophy in India.
The Procedure:
It’s simple and safe because it involves injections instead of surgery. The process includes obtaining adult stem cells from the patient’s bone marrow, which are then processed in a specialized lab for injection back into the patient.
There are three steps involved in the procedure. For more information on this read here.
The Benefits:
Stem cell therapy has been shown to improve:
- Physical activity,
- Muscle strength, and
- Overall aid in the patient’s quality of life.
Additionally,
- It can also reduce inflammation,
- Slow the progression of the disease,
- Restructuring of tissues, and
- Prevention of cell death.
So, it is important to discuss all potential risks with a healthcare provider before undergoing stem cell therapy.
What is the success rate of stem cell treatment for limb-girdle muscular dystrophy treatment in India?
In 2012, cell therapy received the Nobel Prize in Medicine, and many consider it the greatest medical breakthrough in history.
In India, cell therapy only uses bone marrow cells that are taken from the patient’s own body.
This treatment is effective in addressing various conditions like Autism, Cerebral Palsy, Muscular Dystrophy, Intellectual Disability, Spinal Cord Injury, Traumatic Brain Injury, and Ataxia. It uses the patient’s own cells, making it a safe and reliable therapy with no risk of contamination or adulteration.
To date, there have been no adverse incidents resulting from cell therapy at Medicoexperts in India. The data indicates that 90% of the patients who received muscular dystrophy cell treatment experienced an improvement in their symptoms. The risk of tumor formation is also eliminated as the therapy effectively regulates cell proliferation.
The goal of this treatment is not just to treat patients suffering from incurable neurological conditions, but also to rejuvenate and restore their health and energy.
What is the treatment cost for limb girdle muscular dystrophy in India?
The cost of treatment for limb-girdle muscular dystrophy (LGMD) in India can vary significantly depending on the type and severity of the condition, as well as the type of treatment that is needed.
In general, the cost of LGMD treatment in India may be lower than in many other countries, but it can still be a significant expense for patients and their families.
The expenses for the treatment may consist of the cost of diagnostic tests, medications, physical therapy, assistive devices, or even surgery.
The cost of treatment of LGMD can vary greatly, depending on the type and severity of the condition. In dollars, the cost can fall between $400 to $7000, which is equivalent to approximately ₹30,000 to over ₹5,00,000.
It is important to discuss the cost of treatment with your doctor and seek financial assistance if needed.
Conclusion
Limb-Girdle Muscular Dystrophy is a complex and progressive neuromuscular disorder that affects hundreds of thousands of people in India.
At Medicoexperts, we believe that stem cell therapy could be a promising treatment option for muscular dystrophy in India. The reliable process has been proven to improve physical activity and muscle strength in LGMD patients. With this therapy, patients can gain better mobility and live a more independent lifestyle.
We strive to provide the best treatment for our patients, and we hope that stem cell therapy can become a viable option for those affected by LGMD. Our team is dedicated to providing comprehensive care and helping families find the resources they need for treatment.
We understand that finding a treatment plan and managing the cost of care can be difficult. Our team is here to help answer any questions you may have and provide support throughout your journey.
Visit our website today and start exploring our wide range of services offered by experienced subject matter experts who care deeply about helping those suffering from LGMD find hope through diagnosis & treatment!
Frequently Asked Questions and patient concerns:
Q1. Will you be able to achieve your desired lifestyle because of LGMD symptoms?
Ans: While the symptoms of LGMD can affect your lifestyle, it is possible to still live a full and meaningful life with the right treatment plan and supportive care.
With proper management, many individuals with LGMD are able to maintain independence and good quality of life for many years.
Q2. How is Limb-Girdle Muscular Dystrophy different from other types of Muscular Dystrophy?
Ans: Limb-Girdle Muscular Dystrophy (LGMD) is a group of rare muscle-wasting diseases that are characterized by progressive weakness and wasting of the muscles in the arms or legs.
LGMD is different from other types of Muscular Dystrophy in that it usually affects the limb muscles first, as opposed to the trunk or face muscles.
LGMD is also caused by a genetic mutation, whereas other types of MD are not. It’s important to discuss your specific diagnosis with your doctor for the best course of action.
Q3. What are the improvements that can be expected from LGMD treatment?
Ans: Treatment for Limb-Girdle Muscular Dystrophy (LGMD) is focused on managing symptoms and slowing the progression of the disease.
With proper treatment, patients may experience improved mobility or strength, better sleep quality, reduced muscle pain, and improved quality of life.
Regular physical therapy and other treatments can help maximize the benefits of LGMD treatment.
Q4. At what age can Limb-Girdle Muscular Dystrophy be diagnosed?
Ans: Limb-Girdle Muscular Dystrophy (LGMD) can be diagnosed at any age. It is usually diagnosed between the ages of 5-15, but it can occur in younger or older individuals as well.
It is important to discuss any symptoms you may be experiencing with your doctor and have them evaluated for potential diagnosis of LGMD.
Q5. Do patients with Limb-Girdle Muscular Dystrophy can have other health problems too?
Ans: Yes, patients with Limb-Girdle Muscular Dystrophy (LGMD) can have other health problems too.
In addition to muscular weakness and wasting, LGMD can also cause other issues such as joint contractures, scoliosis, breathing difficulties, and heart problems.
It is important to discuss any potential symptoms with your doctor so that you can receive the appropriate care and treatment.
Q6. What is the current status of stem cell therapy from the regulatory framework?
Ans: The stem cell-based therapy is in the research phase and not yet formally approved by ICMR. However, the application of stem cells, popularly known as bone marrow transplants, in blood-related disorders is approved by ICMR.
MedicoExperts is a Global virtual hospital which is established to offer quality healthcare services at affordable pricing without compromising the success rates of the treatment.
MedicoExperts is having a network of highly experienced super specialist doctors and well equipped hospitals across the globe and offering second opinion through online video consultation and surgical interventions through its empanelled super specialist doctors at its network hospitals in 17 countries from 3 continents.
By the virtue of its approach and model, MedicoExperts is successfully achieve to deliver
- Latest and most advanced treatments with success rates of international benchmarks.
- Multiple cost options depending upon the hospital facilities, with the same doctor.
- Treatment option in multiple cities/state/countries.
- Trust and peace of mind.
Most suitable for patients who are looking for:-
- Planned Surgeries and treatment from most experienced doctors and at multiple cost options as per hospital facilities with best possible outcomes.
- Second Opinion from expert doctors.
- Complex cases involving multi specialities
- International patients looking for treatment from Indian doctors
