Sickle cell disease is an illness that lasts for a lifetime. Effective medications are available that can decrease symptoms and prolong life. Also contributing to better well-being are early diagnosis and regular medical care to prevent complications. A bone marrow transplant is presently the most effective method to treat sickle cell disease.
Sickle cell anemia is a hereditary type of anemia — a disease in which healthy red blood cells produce insufficient oxygen level throughout your body. The shape of the cell becomes deformed in sickle cell anemia, becoming stiff and crescent-shaped (or sickle-shaped). The sickle-shaped red blood cells easily break apart, causing anemia. Sickle blood cells cannot function appropriately and suffer premature death (they live only 10-20 days instead of the standard 120 days).
Sickle cell disease is a group of red cell diseases which have been inherited. People with sickle cell disease have abnormal protein in their red blood cells. Sickle cell anemia treatment in India is a life-saving and pain-relieving procedure that will bring relief to the patient. The assured and tried procedure to treat sickle cell disease is receiving a bone marrow transplantation.
Bone marrow transplantation in India is a remarkable and extremely effective treatment procedure to treat sickle cell anemia. The treatment can alleviate pain and help avoid disease-related problems.
The objective of treating sickle cell disease in India is to manage and control symptoms and limit the number of crises. People with sickle cell disease need to be treated continuously, even if there is no crisis. It is best to care for patients with sickle cell anemia from your healthcare provider.
Reasons for sickle cell treatment in India
Sickle cell treatment cost in India depends upon the treatment advised according to the patient’s condition.
The sure way of treating sickle cell disease is by undergoing a bone marrow transplant Cost of bone marrow transplantation in India starts from 15000 USD and depends on the type of bone marrow transplantation.
A pre-operative evaluation is done to determine the best suited approach. A preliminary evaluation is a must to determine the condition and to propose best suited treatment.
Sickle cell anemia is triggered by a gene mutation that causes your body to create the red, iron-rich compound that provides its red (haemoglobin) colour to the blood. Haemoglobin enables red blood cells to transport oxygen to all areas of your body from your lungs. The abnormal haemoglobin in sickle cell anemia leads the red blood cells to become stiff, sticky, and misfit.
SCD is caused by a defective gene called a sickle cell gene. In an inheritance pattern called autosomal recessive inheritance, the sickle cell gene is carried from generation to generation. This implies that for a baby to be affected, both the mother and the father must pass on the faulty gene type.
If you’re born with a sickle cell gene, it’s called the sickle cell trait. People with sickle cell trait are usually healthy, but they can pass on to their kids the faulty gene. SCD’s cause is a defective gene, called a sickle cell gene. There are two sickle cell genes born to people with the disease, one from each parent.
Sickle cell anemia – signs and symptoms
The indication of sickle cell disease is not evident until the child is four months or older. Early symptoms of sickle cell disease include inflammation of the hands and feet; anaemia symptoms, including exhaustion or severe fatigue; and jaundice.
Over time, sickle cell disease can cause complications like illnesses, delayed development and pain episodes, called pain crises. Most kids with sickle cell disease are pain-free in-between crises. In cases of youth and adults, there can be chronic, continued pain. Over a lifetime, spleen, brain, eyes, lungs, liver, heart, kidneys, penis, joints, bones, or skin can be affected by sickle cell disease.
Sickle cell disease can be easily diagnosed by blood test. The blood test will reveal whether you have sickle cell disease or sickle cell traits. This will help to plan for the further treatment protocol.
Medicines used to treat anemia of sickle cells include antibiotics, pain relieving medications and use of certain drugs.
Blood transfusions boost the amount of ordinary circulating red blood cells, helping to ease anemia. Regular blood transfusions can decrease the risk of stroke in children with sickle cell anemia at high risk of stroke.
In order to prevent disease in all kids, childhood vaccinations are essential. But for kids with sickle cell anemia, these vaccinations are even more essential, as infections can be serious in kids with sickle cell anemia.
Breathing extra energy through a breathing mask adds oxygen to your blood and makes it simpler for you to breathe. If you have acute chest syndrome or a crisis of sickle cell, it may be useful.
Bone marrow transplant includes replacing sickle cell anemia impacted bone marrow with a healthy bone marrow.
Bone marrow transplant for sickle cell anemia in India
A bone marrow transplant replaces the cells that create red blood cells in your body with fresh ones. That implies your body will stop producing the disease-causing sickle-shaped cells. In this procedure, a doctor requires healthy cells from a donor’s bone marrow and injects them into your body, generally in one of your veins through an IV tube. The cells go into your bone marrow once inside and begin to create healthy blood cells.
Bone marrow transplantation is the most effective treatment protocol in treating sickle cell disease (SCD). For a patient to have the greatest opportunity for a successful transplant, a well-matched donor is required. Blood and bone marrow transplants in India are effective in approximately 90% of instances involving children related to the recipient and matched with HLA (human leukocyte antigen). Medication is administered to avoid rejection of the transplanted bone marrow.
Sickle cell treatment success rate in India
With the novel approach of bone marrow transplantation, the success rate of sickle cell disease has risen as high as 90% amongst our patients. There is a 95% success rate in patients who had HLA identical sibling bone marrow transplantation in sickle cell disease (SCD)
Frequently Asked Questions and patient concerns:
1. Does sickle cell anemia differ from sickle cell trait?
Yes. An individual in their red blood cells can have a combination of ordinary and defective haemoglobin without sickle cell disease. This disease is called “sickle cell syndrome.” People with sickle cell traits have red blood cells which have sufficient haemoglobin that can stop the cells from sickling or getting diseased.
It is vital to remember that there is no sickle cell illness in individuals with sickle cell trait. Except in uncommon conditions, they generally do not develop sickle cell disease. People with sickle cell trait may, however, pass the characteristic genetically to their kids. If two individuals with sickle cell trait have kids together, their kids will have a 1 in 4 opportunity of sickle cell anemia.
2. What is the likelihood of my kid having sickle cell anemia or sickle cell trait being born?
If both you and your partner have sickle cell traits, there is a 25 per cent possibility that your baby will be born with sickle cell anemia. If only one of you has sickle cell characteristics, your baby can not be born with sickle cell anemia, but there is a 50% possibility that your child will be born with sickle cell characteristics.
3. How does an individual get sickle cell anemia?
The disease is inherited by people with sickle cell anemia, which implies that their parents pass the disease on to them as part of their genetic makeup. Parents cannot pass on to their kids sickle cell anemia unless both of them have the defective haemoglobin in their red blood cells.
4. What are the medical issues created by sickle cell disease?
Sickle-shaped red blood cells tend to block blood flow in tight blood vessels. This may cause organ harm including spleen, liver, and kidney damage. Other complications include episodes of pain and issues with the lungs.
5. Who is mostly affected by sickle cell trait?
A huge number of people worldwide have sickle cell traits. Majority of the people of African ancestry have the sickle cell trait, however this is not exclusive to them.
6. Can sickle cell disease be acquired?
Sickle cell is a condition inherited. In no other manner can it be acquired.
7. When is it advised to seek medical assist for sickle cell trait?
Individuals should see a doctor when they notice blood in their urine, experience eye trauma, or have heat exhaustion or an incident comparable to that.
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