Burn wound healing is a series of complex processes which are subject to intensive investigations to improve the outcomes, the healing time and the quality of the scar. Severe Burn injuries have always proven to have devastating effects on the affected patients. Stem cells helps in superior healing of the wounds and helps in decreasing the inflammation levels with less scar progression and fibrosis.
In the case of wound healing, different types of stem cells have been used for different types of wounds. Burnwounds have proven to be capable of having a devastating effect both functionally and cosmetically, necessitating the search for a better and more efficient cure. Stem cells are undifferentiated pluripotential cells that can regenerate to any other types of cells, including new stem cells identical to mother cells. Stem cells can be of embryonal origin or adult origin, depending on the type of tissue they are derived from. Embryonal stem cells are derived from either embryonal tissue or from germ cells in adults. And the adult stem cells are derived from adult tissues of different organs, especially those with a high turnover rate such as intestines and bone marrow.
Stem cells have been very effective and promising in the healing of wounds. However, the methods of using the stem cells in burn wound healing are different like topical application, local injection, intravenous or systemic injection, and dermal or carrier application. Several studies have shown the efficacy of stem cells in promoting faster and superior wound healing.
Stem cell therapy for wounds healing has proven more efficient by their proliferative effect on keratinocytes. Moreover, this effect of stem cells was found to be mediated by keratinocyte growth factor-1 (KGF-1) and platelet derived growth factor-BB (PDGF-BB).
Additionally, stem cells are not integrating permanently in the tissue, thus, suggesting that their effect is due to released factors and not by direct interaction. Additionally, bone marrow derived mesenchymal stem cells have also been used in wound healing.
Physiology of Burn Wound Healing
The stem cells play a role in promoting wound healing in burns.Concerning the physiology stem cells enhance the process of burn wound healing. Hencean increased levels of bone marrow produces endothelial progenitor cells in burn patients. These levels are proportional to the extent of the burn. Focusing on the role of cytokines in burn wound healing, amnion produces cellular cytokine solution. The amnion produces multipotent progenitor cells to harvest cytokines and apply them in burn wound healing. Cellular Cytokine solution shows significant improvement in the epithelialization of the burn wounds and the appearance of hair growth compared to controls. Stem Cells have an active role in burn wound healing by producing bioactive peptides, such as thymosin 4 and others.
Mesenchymal stem cells stimulate the formation of a basket weave organization of collagen in bleomycin treated skin, like normal skin. Stem Cell treatment of the skin decreases markers of myofibroblasts and down regulated type I collagen, leading to a decrease in the fibrosis that could have occurred to the skin.The role of stem cells in decreasing bleomycin induced fibrosis may be extrapolated to decrease fibrosis in burn wounds and improve their healing with less scar formation. It induces leucine-rich repeat-containing G-protein-coupled receptors which are markers of adult epithelial stem cells both in skin and intestine.
The process of burn wound healing involves different types of growth factors, receptors, and cytokines. These factors are related to stem cell homing, differentiation, and proliferation therefore when applied to burn wounds, it leads to a better and faster healing process.
HBOT for Burn Wound Treatment
Therapeutic use of HBOT in burns is most often utilized for second and third degree burns cases. In third degree burns, the initial thermal injury occurs followed by circumferential, widening tissue loss which means that the surrounding tissue of the burn also becomes damaged because the blood vessels have been destroyed because of the burn. When the blood vessels are destroyed, downstream blood flow from the burn site is arrested, propagating further tissue death due to lack of oxygen.
HBOT given within the first 48 to 72 hours following thermal injury increases the oxygen saturation to the body by up to 12 times that of breathing air at sea level. This can mitigate ischemia reperfusion injury and the possibility of advanced tissue destruction beyond the initial area of thermal injury by supplying the body with added oxygen that, in turn, can bring the damaged area “back to life.” This signals the body that the tissue is no longer a foreign invader and consequently, normal wound-healing processes can take place.
Beyond 72 hours, HBOT helps by continuing to promote new tissue growth, which encourages healing by aiding in the manufacturing of new blood vessels, which, in turn, make fibroblasts that are responsible for collagen production. In addition, HBOT reduces the body’s inflammation which otherwise would slow down the healing process. Finally, HBOT also offers infection control, as oxygen is the white blood cell’s weapon to kill bacteria.
Stem Cells decreases cell infiltration, wound contraction, fibrosis, scar progression, and inflammation of burn wounds. Moreover, it promotes faster burn wound healing and angiogenesis along with better granulation and the formation of hair follicles and sebaceous glands.
Stem cells have proved to be efficient not only in skin burns but also in corneal chemical burns. With the advance of burn wound treatment with time, patient’s self-esteem the quality of life has been improving.
The hope is that the use of stem cells will open a new arena of possibilities to improve the wound healing in burn patients, allowing patients to have faster healing, better scars, and a higher quality of life. In brief, the use of stem cells in burn wound healing appears to be very promising.
Additionally, stem cells involved in the burn wound healing along with their factors and signals constitute a very dynamic and promising effect on the burn wounds.
Cost of Stem Cell Therapy with HBOT
India have the most affordable places for Stem Cell treatment across the globe. We certainly understand that if you have chosen to travel overseas for Stem Cell treatment, then you are indeed looking for cost effectiveness. When you speak about the best, MedicoExperts is the name you can trust on.
Modern technology, State of the art hospitals, experts, specialists, excellent infrastructure at par with international standards, no language barrier, personalized attention, safe surgery and seamless travel are some of our zeniths which magnetizes individuals worldwide to get their Stem Cell treatment in India done through us.
The patient must stay for 12-15 days, however in some cases 45 days of stay is recommended. The approximate cost of Stem Cell Treatment would range between USD 2000 to USD 10000 per cycle depending on current condition of the patient. Hyperbaric treatments average cost is between 50-90 USD per session, each of 60-90 minutes for 25-30 days daily.
Frequently Asked Questions and patient concerns:
1. What is regenerative medicine?
The aim of regenerative medicine is to repair organs or tissues weakened by disease, aging or trauma in a manner that restores or at least improves function. Stem cells are widely used in many ways in regenerative medicine research and therapies. For example, stem cells or unique cells derived from stem cells are administered in the laboratory, or drugs that coax stem cells that are already present in tissues are administered to restore the tissue involved more effectively.
2. How does stem cell therapy for burn injury help?
The aim of stem cell therapy for burn wound healing is to completely rebuild and restore the original structure and functionality of the skin while minimizing complications such as hypertrophic scarring and contracture. One of the ways this can be done is by increasing the natural healing mechanism of the skin using the stem cells’ regenerative potential. In addition, they have been shown to facilitate faster burn wound healing and angiogenesis, along with improved granulation and hair follicle and sebaceous gland development.
3. What are the treatment options for burn injury?
The treatment of wounds can vary from the application of ointments for mild burns to debridement and skin grafts for serious burns, depending on the severity of the burn. For the treatment of second- and third-degree burns affecting more than 18% of the body surface area, hyperbaric oxygen therapy (HBOT) may also be recommended. You may also use hyperbaric oxygen therapy (HBOT) to improve your burn pain management, in addition to any skin grafting or other external therapies your burn wound requires. One of the only therapies available to enhance the internal responses of your body to burn wounds is HBOT.
4. How many sessions will I need?
You’ll definitely need more than one session to benefit from hyperbaric oxygen therapy. Your medical condition is contingent on the number of sessions. Some patients could also need several sessions, depending on the degree of the burn injury. Hyperbaric oxygen therapy is typically part of a comprehensive care plan supplied with other medications and medicines that are tailored to meet the particular needs in order to efficiently treat approved medical conditions.
5. What happens after HBOT session is complete?
The medical team will assess you by looking in your ears and taking your blood pressure and pulse. If you have diabetes, your blood glucose is checked. Once the team decides you are ready, you can get dressed and leave. You may feel somewhat tired, light-headed or hungry following your treatment. However, these symptoms will usually go away after a short period of time and should not hinder your routine activities.
6. How long does a treatment last?
A typical treatment generally lasts a bit over two hours. Of course, treatments can sometimes take longer, especially if patients have difficulty clearing their ears during the pressurization phase.
MedicoExperts is a Global virtual hospital which is established to offer quality healthcare services at affordable pricing without compromising the success rates of the treatment. MedicoExperts is having a network of highly experienced super specialist doctors and well equipped hospitals across the globe and offering second opinion through online video consultation and surgical interventions through its empanelled super specialist doctors at its network hospitals in 17 countries from 3 continents.
By the virtue of its approach and model, MedicoExperts is successfully achieve to deliver
- Latest and most advanced treatments with success rates of international benchmarks.
- Multiple cost options depending upon the hospital facilities, with the same doctor.
- Treatment option in multiple cities/state/countries.
- Trust and peace of mind.
Most suitable for patients who are looking for:-
- Planned Surgeries and treatment from most experienced doctors and at multiple cost options as per hospital facilities with best possible outcomes.
- Second Opinion from expert doctors.
- Complex cases involving multi specialities
- International patients looking for treatment from Indian doctors