Proton beam therapy to treat Liver cancer

What is liver cancer?

Cancer that originates in the liver is termed as liver cancer. The liver is one of the largest organs of the body and it lies below the diaphragm and above the stomach in the upper right section of the abdomen. Several cancer types can occur in the liver. Hepatocellular carcinoma is the most common type of liver cancer, originating in the main type of liver cell (hepatocyte).Liver cancer

Typically, liver cancer is categorized as primary or secondary. Primary liver cancer starts in the liver cells. Secondary cancer of the liver or liver metastasis develops when the cancer cells spread to the liver from another organ. Different types of primary liver cancer are found depending on the different cells that make up the liver. People with severe damage to the liver are more likely to develop multiple sites of cancer.

A person with liver cancer will experience a mass or pain on the right side of the stomach and skin yellowing. Unfortunately, until the cancer is advanced, you may not display any symptoms. This makes treatment tricky and complicated.

What are the treatment options available for liver cancer?

The most common type of liver cancer is hepatocellular carcinoma (HCC), also known as hepatoma, which accounts for 75% of all liver cancers. Liver cancer treatment depends on a number of factors like size, site, location, the functionality of the liver, if there is cirrhosis and if cancer has spread to the adjacent organs.

Doctors use liver and blood tests to diagnose cancer of the liver. The standard model of treatment for liver cancer includes surgery, radiation, chemotherapy, or liver transplantation.

However, at times, owing to the complexity of the site of the tumour, surgery is not always an option. But thanks to the advancement in technology and surgical innovation, newer and more viable options are emerging as a potential treatment for liver cancer.

Additionally, in patients with hepatocellular carcinoma (HCC) which is a type of liver cancer with the highest mortality rate and limited treatment options, proton beam therapy is emerging as a significant option.

Why proton beam therapy?

The standard treatment protocol for HCC includes liver transplants, surgical resection, ablative treatments, and radiation therapy — either photon (traditional radiation therapy using x-rays or gamma rays) or proton radiation therapy (which provides more focused radiation using high-speed positively charged particles). However, proton beam therapy (PBT) is proving to be a probable option.Proton beam therapy

During PBT, protons are accelerated by a machine called a synchrotron or cyclotron. The protons’ high velocity creates high energy. This energy causes the protons to travel to the intended body depth. The protons then give in the tumour the targeted dose of radiation. There is less radiation dose outside the tumour with proton therapy. In X-rays radiation therapy, the x-rays continue to give radiation doses as they leave the body of the person, which means that radiation also affects healthy tissues in the region, which may cause side effects. This is not the case in PBT. PBT provides minimal dose to nearby healthy organs compared to X-ray therapy (XRT), which is especially pertinent for the treatment of liver cancers since the mean and low dose to the liver is among the most significant factors of radiation-induced liver disease (RILD). High-dose PBT in patients with HCC has been shown to achieve excellent long-term tumour control with minimal toxicity. Growing evidence recommends PBT in patients with unresectable cholangiocarcinoma or hepatic metastasis, especially to those with larger tumours who are unlikely candidates for XRT.

Undergoing PBT is a painless process, and the number of sessions depends upon the size, type and stage of liver cancer. PBT is an essential treatment option for cancer which are near critical organs. It is also possible to use PBT to treat these cancers:

  • Cancer of the central nervous system like malignant meningioma, chordoma, etc.
  • Cancer of the eyes
  • Cancer in the head and neck region
  • Lung cancer
  • Prostate cancer
  • Spinal and pelvic cancer (which occur in the bone and soft-tissue)
  • Non-cancerous brain tumours

To know more about liver cancer treatment with proton beam therapy, feel free to write to us at or give us a call at +91- 9769516280

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